The aim of present work was to study the comparative antimicrobial activity of extract of Tinospora cordifolia (T. cordifolia), Merremia emarginata (M. emarginata) against different microbial species. The physiochemical parameter extractive values of both the drugs were determined for the selection of solvent by using chloroform, ethyl acetate and ethanol by soxhlet extraction. Extract of both individual drugs and combined drugs were prepared. Culture of microbial species of Salmonella typhi (S. typhi), Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis) were prepared and zone of inhibition were checked by using individual extract of drug and combined extract drug. Both drugs shows antimicrobial activity against different microbial species as well as extract of combined drugs also showed good antimicrobial activity. Combined extract of T. cordifolia and M. emarginata showed more zone of inhibition against S. typhi. The obtained experimental data serve as useful guide for antimicrobial activity of combined effect of T. cordifolia and M. emarginata against S. typhi, S. aureus and B. subtilis. The combination of extract of two drugs shows optimal antimicrobial activity against S. typhi.
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